Mac Studio Bluetooth randomly disconnects from Apple accessories (Magic mouse, trackpad, keyboard)

I have the same issue... I don't believe anything would disturb the devices, as even in a completely secluded mountain hotel, they released my peripherals, like mouse, keyboard, trackpad, 2-3 times a day. Interestingly, it never released the AirPods Pro 2, only the peripherals, even when I only allowed the mouse. There are many similar complaints online. Unfortunately, I haven't found a solution. It's not true that frequency congestion is responsible; I've given it plenty of time to test.

This drives me absolutely nuts and is especially frustrating when playing a computer game such as Minecraft. I'll find my character is frozen while a zombie or other bad guy pummels "me" to oblivion.

So far my saving grace is Handoff and a nearby Mac that lets glide the mouse cursor over to the Mac Studio's screen and take over.

But I found an even better way. I've got an external third-party USB-connected keypad popular with video game streamers. One of the keys I've programmed to be "Reset Bluetooth". When pressed, it does `sudo pkill bluetoothd` and that solves the problem. My Apple-branded mouse, keyboard, and trackpad all reconnect in seconds.

This tells me it's not an interference issue (as oft suggested), but is instead software.

Bluetooth uses the same radio, Wi-Fi 2.4 GHz band, that is so vulnerable to interference from badly-shielded USB-3 accessories and crummy cables. But instead of one channel, it uses frequency-hopping in an attempt to maneuver around Wi-Fi data and interference.

That is why the Interference summary above is applicable.

Why do I have difficulty with Wi-Fi or Bluetooth devices when USB 3 devices are attached to my computer?

Some USB 3 devices can generate radio frequency interference that can cause Wi-Fi and Bluetooth devices operating in the 2.4GHz band to have issues communicating with your computer. Here are some tips to avoid this issue:

• If your USB device has a cable long enough that you can move the device, place it away from your Mac—and make sure not to place it behind your Mac, or near the hinge of its display. The antennas for Wi-Fi and Bluetooth are located there, and USB 3 devices placed there might interfere with your wireless connections.

• If you're using adapters or dongles on a Mac computer with Thunderbolt 3 (USB-C) ports, plug them into the front port on the left side of your Mac, or into the ports on the right side (if your computer has them). These ports are the farthest away from the antennas, making interference less likely.

• To avoid interference on the 2.4GHz band using Wi-Fi, try using the 5GHz band instead. You can change this on your wireless base station. Bluetooth always uses 2.4GHz, so this alternative isn't available for Bluetooth.

from:

About USB on Mac computers - Apple Support

Resolve Wi-Fi and Bluetooth issues caused by wireless interference

Resolve Wi-Fi and Bluetooth issues caused by wireless interference - Apple Support

I have the same issue. It started very rarely, no more than once a day and reconnected after 3-5 seconds. It's now annoying about once every two hours and sometimes it takes more than 2-3 minutos to recconnect.

Did you find any solution?

2.4 GHz Wi-fi and bluetooth is also subject to interference from baby monitors, microwave ovens, and cordless landline phones, among others.

The biggest threat is badly-shielded USB-3 cables or devices, but some other cables like HDMI cables have also been implicated.