panic(cpu 12 caller 0xffffff801e489d2a): Sleep transition timed out after 180 seconds while entering darkwake on way to sleep. Suspected bundle: com.apple.driver.usb.AppleUSBXHCI. Thread 0x165cb6.
Backtracing specified thread
Backtrace (CPU 12), Frame : Return Address
0xffffffa1bbe33848 : 0xffffff801dde878b 
0xffffffa1bc5fbc00 : 0xffffff801dcde972 
0xffffffa1bc5fbc70 : 0xffffff801dcdd40f 
0xffffffa1bc5fbcc0 : 0xffffff801dde5746 
0xffffffa1bc5fbd00 : 0xffffff801dde4fab 
0xffffffa1bc5fbd30 : 0xffffff801e416528 
0xffffffa1bc5fbd60 : 0xffffff801e4195e9 
0xffffffa1bc5fbdc0 : 0xffffff801e3fd260 
0xffffffa1bc5fbe60 : 0xffffff801e3fcb44 
0xffffffa1bc5fbe80 : 0xffffff801dcff725 
0xffffffa1bc5fbef0 : 0xffffff801dd00634 
0xffffffa1bc5fbfa0 : 0xffffff801dc5f13e 

Process name corresponding to current thread: kernel_task
Boot args: chunklist-security-epoch=0 -chunklist-no-rev2-dev

Mac OS version:
20D91

Kernel version:
Darwin Kernel Version 20.3.0: Thu Jan 21 00:07:06 PST 2021; root:xnu-7195.81.3~1/RELEASE_X86_64
Kernel UUID: C86236B2-4976-3542-80CA-74A6B8B4BA03
KernelCache slide: 0x000000001da00000
KernelCache base:  0xffffff801dc00000
Kernel slide:      0x000000001da10000
Kernel text base:  0xffffff801dc10000
__HIB  text base: 0xffffff801db00000
System model name: MacBookPro16,1 (Mac-E1008331FDC96864)
System shutdown begun: NO
Hibernation exit count: 24

System uptime in nanoseconds: 189380169586792
Last Sleep:           absolute           base_tsc          base_nano
  Uptime  : 0x0000ac3d81bc5afd
  Sleep   : 0x0000a28b71fe5526 0x00001310dec82e1a 0x0000a288ca3cdadf
  Wake    : 0x0000a28ba4925f23 0x000019c112cf1b3e 0x0000a28b83ca914a
last started kext at 188790753725932: >usb.!UUserHCI	1 (addr 0xffffff7fbe59f000, size 102400)
last stopped kext at 189232615664788: >AudioAUUC	1.70 (addr 0xffffff7fbe185000, size 12288)
loaded kexts:
com.paragon-software.filesystems.ntfs	105.8.15
|SCSITaskUserClient	436.40.6
>AGPM	119
>!APlatformEnabler	2.7.0d0
>X86PlatformShim	1.0.0
@filesystems.autofs	3.0
@fileutil	20.036.15
>!ATopCaseHIDEventDriver	4030.5
>!AHIDALSService	1
@kext.AMDRadeonX6000	4.0.2
@kext.AMDRadeonServiceManager	4.0.2
>!AUpstreamUserClient	3.6.8
>AGDCBacklightControl	6.2.2
>!ABridgeAudio!C	100.2
>!AGraphicsDevicePolicy	6.2.2
>!A!IKBLGraphics	16.0.1
@AGDCPluginDisplayMetrics	6.2.2
>pmtelemetry	1
>LuaHardwareAccess	1.0.16
|IOUserEthernet	1.0.1
|IO!BSerialManager	8.0.3d9
@Dont_Steal_Mac_OS_X	7.0.0
>!AHV	1
>!ADiskImages2	1
>!AMCCSControl	1.14
>!A!ISlowAdaptiveClocking	4.0.0
>!A!ICFLGraphicsFramebuffer	16.0.1
>!AMuxControl2	6.2.2
>BridgeAudioCommunication	100.2
>!AAVEBridge	6.1
>!AGFXHDA	100.1.431
>!A!IPCHPMC	2.0.1
>!AThunderboltIP	4.0.3
>BCMWLANFirmware4378.Hashstore	1
>BCMWLANFirmware4377.Hashstore	1
>BCMWLANFirmware4364.Hashstore	1
>BCMWLANFirmware4355.Hashstore	1
>!ABCMWLANBusInterfacePCIeMac	1
@filesystems.tmpfs	1
@filesystems.hfs.kext	556.60.1
@BootCache	40
@!AFSCompression.!AFSCompressionTypeZlib	1.0.0
@!AFSCompression.!AFSCompressionTypeDataless	1.0.0d1
@filesystems.apfs	1677.81.1
@private.KextAudit	1.0
>!ASmartBatteryManager	161.0.0
>!AACPIButtons	6.1
>!ASMBIOS	2.1
>!AACPIEC	6.1
>!AAPIC	1.7
@!ASystemPolicy	2.0.0
@nke.applicationfirewall	310
|IOKitRegistryCompatibility	1
|EndpointSecurity	1
@kext.triggers	1.0
>!AHIDKeyboard	223
>!AHS!BDriver	4030.5
>IO!BHIDDriver	8.0.3d9
>!AActuatorDriver	4400.28
>!AMultitouchDriver	4400.28
>!AInputDeviceSupport	4400.35
@kext.AMDRadeonX6100HWLibs	1.0
>!ABacklightExpert	1.1.0
@kext.AMDRadeonX6000Framebuffer	4.0.2
|IO!BHost!CUARTTransport	8.0.3d9
|IO!BHost!CTransport	8.0.3d9
@kext.AMDSupport	4.0.2
>X86PlatformPlugin	1.0.0
>!A!ILpssUARTv1	3.0.60
>!A!ILpssUARTCommon	3.0.60
>!AOnboardSerial	1.0
|IOAVB!F	930.1
>!ASMBus!C	1.0.18d1
@!AGPUWrangler	6.2.2
|IOSlowAdaptiveClocking!F	1.0.0
|IOAccelerator!F2	439.52
>!AGraphicsControl	6.2.2
@!AGraphicsDeviceControl	6.2.2
|IONDRVSupport	585
|IOAudio!F	300.6.1
@vecLib.kext	1.2.0
@kext.AMDRadeonX6000HWServices	4.0.2
|IOGraphics!F	585
>IOPlatformPlugin!F	6.0.0d8
@plugin.IOgPTPPlugin	900.11
|IOEthernetAVB!C	1.1.0
>usb.!UHub	1.2
>usb.cdc.ncm	5.0.0
>usb.cdc	5.0.0
>usb.networking	5.0.0
>usb.!UHostCompositeDevice	1.2
>!ABCMWLANCoreMac	1.0.0
|IOSerial!F	11
|IO80211!FV2	1200.12.2b1
>IOImageLoader	1.0.0
>corecapture	1.0.4
>!AThunderboltPCIDownAdapter	4.1.1
>!AThunderboltDPInAdapter	8.1.4
>!AThunderboltDPAdapter!F	8.1.4
>!AHPM	3.4.4
>!A!ILpssI2C!C	3.0.60
>!A!ILpssI2C	3.0.60
>!A!ILpssDmac	3.0.60
>!ABSDKextStarter	3
|IOSurface	289.3
|IOSkywalk!F	1
>mDNSOffloadUserClient	1.0.1b8
@filesystems.hfs.encodings.kext	1
>usb.!UVHCIBCE	1.2
>usb.!UVHCICommonBCE	1.0
>usb.!UVHCI	1.2
>usb.!UVHCICommon	1.0
>!AEffaceableNOR	1.0
|IOBufferCopy!C	1.1.0
|IOBufferCopyEngine!F	1
|IONVMe!F	2.1.0
>!AThunderboltNHI	7.2.8
|IOThunderbolt!F	9.3.2
|IOUSB!F	900.4.2
>usb.!UXHCIPCI	1.2
>usb.!UXHCI	1.2
>!AEFINVRAM	2.1
>!AEFIRuntime	2.1
>!ASMCRTC	1.0
|IOSMBus!F	1.1
|IOHID!F	2.0.0
$!AImage4	3.0.0
|IOTimeSync!F	900.11
|IONetworking!F	3.4
>DiskImages	493.0.0
|IO!B!F	8.0.3d9
|IOReport!F	47
|IO!BPacketLogger	8.0.3d9
$quarantine	4
$sandbox	300.0
@kext.!AMatch	1.0.0d1
|CoreAnalytics!F	1
>!ASSE	1.0
>!AKeyStore	2
>!UTDM	511.60.2
|IOUSBMass!SDriver	184.40.6
|IOSCSIBlockCommandsDevice	436.40.6
|IO!S!F	2.1
|IOSCSIArchitectureModel!F	436.40.6
>!AMobileFileIntegrity	1.0.5
@kext.CoreTrust	1
>!AFDEKeyStore	28.30
>!AEffaceable!S	1.0
>!ACredentialManager	1.0
>KernelRelayHost	1
|IOUSBHost!F	1.2
>!UHostMergeProperties	1.2
>usb.!UCommon	1.0
>!ABusPower!C	1.0
>!ASEPManager	1.0.1
>IOSlaveProcessor	1
>!AACPIPlatform	6.1
>!ASMC	3.1.9
|IOPCI!F	2.9
|IOACPI!F	1.4
>watchdog	1
@kec.pthread	1
@kec.corecrypto	11.1
@kec.Libm	1


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Time of the the issue: 10/04/21@18:23 after using 5TB G-Technology