Thank you for suppling the Limited Access Report. That said, as we have Limited Access Report - the below analysis will also be equally limited To be straight forwards about the below and with Respect to the user. The user may consider performing, from below image and remove all content from this computer and start again. This time being very very selective as to what is installed on this computer. Further, would NOT use A Time Machine Backup ( if one exists ) to Restore anything from that drive to the New Installation. Doing so, >>> Issues that may exist on the TM Backup Drive when the last Backup was performed will be migrated to the New Installation on this Computer. This would badly pollute the new Original and Pristine installation of the new OS. <<< Performance: Excellent Problem: Other problem Description: All the permission request dialog boxes fail to response and canâ t be closed since macOS Monterey 12.4 Major Issues:   Anything that appears on this list needs immediate attention.  Q 1 -  Proxies - Network proxies detected. This could be evidence of malware. A 1 - The The Built in Security  is all that is required to protect the computer. There is Adware & Malware which will affect the computer and is generally downloaded from â Shady â Websites or Developers who Inject this software into the download. Should â Certain & Specific Software â referenced from above be installed - it will negatively impact macOS. It is suggested, to download directly from a respected ASC Contributor, the application Malwarebytes for Mac.  It is free or paid for added features.  Run the Application and it should remove the malware / adware. Once done, restart computer and test. Q2 - Unsigned files - There are unsigned software files installed that could be malicious and should be reviewed. A2 - This is self explanatory and the User ( you ) needs to evaluate this software. Q 3-  Gatekeeper disabled - Gatekeeper security protection is disabled. This computer is at risk of malware infection. A 3 - This is self explanatory and the User ( you ) needs to decide what is Best for this computer Q 4 - Automatic updates disabled - Automatic updates are disabled. This computer is at risk of malware infection. A 4 - This is self explanatory and the User ( you ) needs to decide what is Best for this computer Q 5-  Security updates disabled - Security updates are disabled. This computer is at risk of malware infection. A 5 - This is self explanatory and the User ( you ) needs to decide what is Best for this computer Q 6 - Apple security disabled - Apple security software is disabled. This computer is at risk of malware infection. A 6 - This is self explanatory and the User ( you ) needs to decide what is Best for this computer Minor Issues: Q 7 - More than one antivirus app - This computer has multiple antivirus apps installed. A 7 - There are no known Windows-like Viruses in the wild that self replicate and affect macOS, because of the underling UNIX  Foundation and Permission Limitation.  The Only thing this Antivirus software is protecting is the Bank Account of the Developers and for zero return to the User aside from the problems this software creates. Q 8 - No Time Machine backup - Time Machine backup not found. A 8 - That would be a normal occurrence since Etrecheck was run without Full Disc Access Q 9- Limited drive access - More information may be available with Full Drive Access. A 9 - That would be a normal occurrence since Etrecheck was run without Full Disc Access    Q 10 - disk6 - Seagate BUP Slim 2.00 TB   External USB 5 Gbit/s USB     disk6s1 - i*******t (MS-DOS FAT12) 2.00 TB A 10- The Drive is running in a Fat 12 Format which is not a Native macOS drive format Therefore the performance of this drive is either being controlled from some Third Party Software ( which is interfering with macOS operations ) and / or will degrade the overall performance of this drive.  Network:   Interface en0: Ethernet   Q 11-   Proxies: HTTP, HTTPS, SOCKS   Interface en4: Ethernet Adapter (en4) Q 12 - Proxies: HTTP, HTTPS, SOCKS Q 13 - Proxies: HTTP, HTTPS, SOCKS Q 14 -   Proxies: HTTP, HTTPS, SOCKS A 11,12,13,14 - All the above has been covered early as in Malware/ Adware having infested this computer. The solution was also covered earlier      Q 15 - Google Chrome.app A 15 - Known Memory Hog and also known to harvest the Personal Data on this computer for the purposes to Sell that Harvest Data to the Highest Bidder . Suggest exploring the www.brave.com to run a Chrome Browser with the Google Q 16 - CleanMyMac X.app A16 - The Gold Standard to causing a Self Inflicted Harm to the Operating System. Any Third Party Applications that will interfere with the normal operation of the OS, alter, modify, remove or delete or attempt to do so is an invitation for disaster and comprising the Operating System Any of the below should be removed as per Developers Instructions  This will include CleanMyMac     Q17 - Antivirus software: Avira and CleanMyMac https://discussions.apple.com/search?q=Avira%20%20antivirus A 17 - Same goes for this unless software