Currently Being ModeratedMar 22, 2012 2:51 PM (in response to AMCarter3)
Yes, they run automatically. If the computer is asleep at the scheduled time then they will run when the computer is available.
Currently Being ModeratedMar 22, 2012 4:50 PM (in response to AMCarter3)
Yes, Apple fixed that issue that they would only run in the early AM when most users have their machines off/sleeping and clog the machine up.
No need to worry about having to do anything anymore unless you have a glitchy issue, then the free OnyX will clean your machine's caches out nicely.