Use Constant Bitrate (CBR) and crank the bitrate up to 7.3 - 7.5 MB/s. Motion Estimation: Best. Turn on Frame Controls and set everything to Better except for the Resize Filter; set that to Best.
But .... do some testing. Many people are not happy with Compressor's scaling so you might want to do separate encodes, one for scale (to ProRes SD) and one for MPEG-2 conversion.
If you need Hollywood quality encoding you might want to look at CinemaCraft .... but that is $$$.