Currently Being ModeratedApr 24, 2012 7:03 AM (in response to winkydude)
Viruses/Malware are almost nonexistent on Macs and I have never heard of one which would do what you are seeing. Forget virus as the first thing when something goes wrong on your Mac. If you have a true virus you'll be famous as the first one in over 10 years.
Have you used Spotlight to see if the files are anywhere else on your computer? What you see in iTunes is a listing of what iTunes thinks you have with reference to a location indicator for a track files. If the files are moved, or folder renamed, iTunes suddenly no longer sees the files where it thinks they should be and gives you a ! 2200 files. Did your computer suddenly gain tens of GB free overnight?