Yes, it is possible. At the set level, which will contain the synth patches, you have to create two "Playback" software instruments tracks and load your .wave in it.
The easiest way to do so is to drag and drop, at your set level, your audio files to the channel strips of your set.
In order to synchronize the transport function of these two playback, you have to assign the two playback to the same Group, (A for example). As a security, assign the same Sync, Snap To, Play From features to the two Playback.