I'm having a similar problem since 10.8.2, but only when I'm logging on. The mouse and keyboard freeze for several minutes (though input keeps being processed... when the freeze ends whatever I typed shows up in the login name box).
I'm not running Radio Silence, but I'll see about what other apps were migrated. Maybe Apple's migration assistant should tag apps and startup items were migrated, and have an option to boot up with *just those* packages disabled...
I have the latest version /b apple wireless keyboard. Have had it for a year now.
Used it 20+ hrs per week on 10.6.8 without a single hiccup.
on Adobe CS and Final Cut
Now on 10.8.2, it's wrecking my head.
Same as :
Same problem with the keyboard. Trackpad not responsive either.