TS4071: iTunes 10.5 for Windows: Installing VoiceOver onto your iPod nano or iPod shuffle requires QuickTimeLearn about iTunes 10.5 for Windows: Installing VoiceOver onto your iPod nano or iPod shuffle requires QuickTime
Currently Being ModeratedOct 16, 2012 8:41 AM (in response to tonirani)
Basic troubleshooting from the User's Guide is reset, restart, restore (first from backup then as new). Try each of these in order until the issue is resolved.
If they do not resolve the issue, this indicates a serious hardware failure. Take the device to Apple for evaluation and possible replacement.