Just downloaded and installed the new iTunes 11. As is usual with Apple the installation completed without issue. The new version 11 is wickedly faster than previous versions. Things have moved around a little so some searching and playing may be required. My iPad 2 (iOS 6.0.1) was found and synced without a problem. I haven't experienced any of the issues being reported by some users.
iMac, OS X Mountain Lion (10.8.2), iPad 2 iOS (6.0)