Our school has about 400 Mac computers running OS 10.5 to 10.8. We are in an open directory environment. When users try to open Adobe Acrobat on their workstation, the application will open, and then immediately unexpectedly quit. I created a test group to allow any and all programs, but the problem persists. This has been happening since we were on a 10.2 server. Preview works perfectly to open .pdf documents, but there are a few applications that require Adobe acrobat to open a master .pdf document to open links to other adobe acrobat documents that do not work in preview.
It is possible the problem is Acrobat Reader not working with network home directories. It is a long time since I looked in to this but I think around about Acrobat Reader 9 Adobe broke the ability to use Reader with network home directories. This bug was originally introduced with Acrobat Pro 7 (but not Reader), fixed in Acrobat Pro 8.1, reintroduced in Acrobat Pro 9 (and Reader 9) and may still exist.
The fix for Acrobat Pro and apparently also Acrobat Reader is to redirect a folder to a location on your local harddisk instead of the (in this case) normal location in your network home directory on the server. See the above article.
Note: With Snow Leopard Server you can automate this redirection.
Unfortunately Adobe are completely brain dead regarding ensuring their applications work properly with network home directories. Their attitude is that they do not support using their software with servers (literally that is what they said).
These days Preview at least in Lion and later is able to do almost anything your average user needs with PDFs including deleting or adding pages, adding notes, even producing password protected PDFs.
PS. Even Microsoft who are notorious for their poor Mac programming do a better job than Adobe with regards to working with network home directories.
The problem is pretty much what John Lockwood talked about in his post. There is a directory that Acrobat is unable to read/write to when it resides in a network home directory.
The fix is to create a symlink to a local directory (I create a folder at /Users/Shared/RedirectData for this purpose).
mkdir -p /Users/Shared/RedirectData/Acrobat/10.0 mkdir -p ~/Library/Application\ Support/Adobe/Acrobat ln -s /Users/Shared/RedirectData/Acrobat/10.0 ~/Library/Application\ Support/Adobe/Acrobat