Yeah, same here after upgrade.
It is not related to any specific application — this behavior and freezes are system-wide, lock up is affecting any input devices — both keyboard and trackpad or connected mouse. Input gets sometimes “buffered” and if I try to switch apps several times with CMD-Tab, after un-freezing I see these keystrokes sent to the system.
It is not related to memory use — my Activity Monitor shows 263 MB of swap use (which is very little).
It is not related to power mode — I see this both on AC and battery.
Seems like some breakage in compressed/decompressed memory procedures in OS X Mavericks. If our Apple Overlords don't fix it soon I will have to roll back to Mountain Lion, because this freezing is very annoying and I have zero buyer's regret about new version because hey, free upgrade, nothing gained, nothing to lose.
(This freezing brings to mind the times when apps were “lifted” from Swap in old sad days of slow drives and memory shortage in Windows. Hang-ups looked similar, only difference is that system didn't lock up all the user input sources.)
MacBook Air 13", 4 GB, Mid 2011