Q: iTunes isn't detecting iPhone

Try restarting the AMDS >  Restart the Apple Mobile Device Service (AMDS) on Windows - Apple Support

Upgrading to Windows 10 (although usually a smooth process) sometimes causes problems with certain drivers also needing to be updated.  I suggest to remove not only iTunes but ALL related components, reboot, remove the target installation folders and reinstall.  See turingtest2's excellent iTunes for Windows Troubleshooting Guide for the instructions at:

Troubleshooting issues with iTunes for Windows updates

especially the sections: Removing and reinstalling iTunes and other software components and iTunes installers

If you still have problems, it would help to know the versions of iTunes & iOS you are using.

If your iOS device isn't showing in iTunes try the following:

1. Open Control Panel > Device Manager
2. Plug in your device
3. Locate Universal Serial Bus Controllers > Apple Mobile Device USB Driver.
   It is also possible the device may show under Imaging Devices, Portable Devices or Other Devices or as an MTB USB Device.
4. Right-click and select Update Driver Software...
5. Click Browse my computer for driver software
6. Browse to C:\Program Files\Common Files\Apple\Mobile Device Support\Drivers or
                   C:\Program Files (x86)\Common Files\Apple\Mobile Device Support\Drivers
7. Click Let me pick from a list of device drivers on my computer
8. Click Apple Mobile Device USB Driver
9. Click Next, then Close and exit Device Manager

For step 3 above, open the device manager. Expand any of these sections that are listed.

• Universal Serial Bus Controllers
• Imaging Devices
• Portable Devices
• Other Devices

Connect the device. You should hear the telltale sound of Windows device connection and one section should gain a new entry. That should be your device. It may not be labelled correctly at this stage. If you don't hear a noise suspect a damaged cable.

Or try If iTunes doesn't recognize your iPhone, iPad, or iPod - Apple Support which is Apple's version of the advice above.

Failing that try a full tear down and rebuild of iTunes as set out in Troubleshooting issues with iTunes for Windows updates. 64-bit users could also try the alternate iTunes for Windows (64-bit - for older video cards) build which is sometimes a useful workaround.

Or lastly try rolling back to the last build of iTunes that worked for you. See iTunes installers for download links. If you're rolling back from 12.4.0.119 to 12.3.3.17 or 12.3.2.35, for example, then you'll also need to roll back the library database using the method described in Empty/corrupt iTunes library after upgrade/crash. The tip includes suggestions for reintroducing any recent purchases so at worst you lose a few playcounts and/or a recently created playlist.

tt2