Q: Advance Mac Cleaner keeps reappearing after moving it to the trash.  How can I remove it permanently?

the developer should have directions on their webpage. dragging to the trash will not uninstall this because it has processes that run when your computer is active, not just when you launch the application manually.

If the pop-up reloads, force quit Safari (command - option/alt - esc) and reopen with the shift key held down. If that doesn't work, disconnect from the Internet, go to Safari/History and delete the website. Quit and reopen with the shift key held down.

Safari – Popup takes over

Safari – Popup takes over (2)

Popup remover – Scam Zapper

The key to getting rid of "Advanced Mac Cleaner" is to quit the app first. If necessary, use Activity Monitor to find it so you can do that: Activity Monitor: Quit a process.

Then, moving it from your Mac's Applications folder to the Trash should work. If that doesn't help write back for additional suggestions. When you do, please indicate the OS X version you have installed. To determine that please read Find the OS X version and build number on your Mac - Apple Support.

I keep receiving the pop up after I updated Adobe.

You succumbed to a common scam that leverages Adobe Flash Player's popularity. Please read Beware bogus Adobe Flash "installers".