I've been running Gentoo on my Mac Pro for quite awhile. I have been extremely happy with it. When I first set it up, there was very little info on setting up linux on the Mac Pro. Besides Gentoo, Fedora will run on on the Mac Pro and so will Ubuntu. Ubuntu has a very active Linux on Intel Macs community. Their forums have been great. The only issue I had with setting up Gentoo was booting off of the cd. I had to boot off of a external usb drive to get it to work correctly. I believe the most recent version of the Gentoo installer doesn't have this issue.
My setup is a Mac Pro with Dual 3.0ghz dual cores, with 10gb of memory, dual raptor drives, dual wd7500aaks drives, and 4 GeForce 7300 cards with 8 monitors. I didn't want to bother with Bootcamp, so I installed rEFIt to handle the booting this way I can still use OS X...although the only times I have done that were to install the SMC Update and a couple of rEFIt updates.
As I remember, dealing with Apples Disk Utility was a nightmare. It was constantly crashing/locking up on me and never produced the same results across various runs. I had to use a 3rd party partitioning tool, but I can't remember which one. When I added the additional drives, I just used one of the command line partitioning tools under linux.
I have setup the 2 gigabit nics to be bonded for performance and failover.
I spent more time screwing around in OS X than I did to install and compile Gentoo with Gnome and lots of extras. The compiling really didn't take that long on the Mac Pro. I had a working system pretty quickly.
In the next few weeks I'll be getting an additional Mac Pro, but this time go octo...even though new Mac Pros are probably on the horizon.