This may help all of you who have had this problem after converting to Leopard. I have spent the last 6 days testing and retesting why I could not drag & drop files or folders, except from my desktop. This occurred ONLY on my Mac Pro and not on my MacBook Pro or an old 12" I use for travel. I tried everything, and I mean everything, including all the recommendations on the Apple site. Today I went out and bought a Microsoft Laser Mouse 6000, as some of the threads discussed Logitech issues. However, even after Zapping all Logitech programs, It was still occurring. I loaded the software for the new mouse and connected the 6000, while disconnecting my Logitech remote, before I reboot. This completely solved my problems, and it has not recurred even after 6 reboots. In the end, the only difference on all the computers was the mouse, and it was the cause of all my "issues." I hope this helps