Grant has already covered the important aspects. If I may add a few comments.
I order for me to access the CD-Rom, I need to install this "CD-ROM" driver on my exisitng SCSI hard drive?
Yes, or onto a bootable floppy.
To do so, am I to understand that I need somehow to download the driver first and then trasport it onto a 800k floppy, then install this ONTO / INTO the existing SCSI hard drive which currently is populated (co-exist) with System v 6.0.8?
Yes. System 6.0.8 is a good and fast operating system for the Macintosh Plus, but it is more difficult to find the appropriate driver software (and the installation per se may be slightly more complicated than with the System 7 variants).
I was hoping to completely re-format the hard drive with fresh install from the System 7.5.3 CD-ROM I purchased from E-Bay. Is this not possible?
Since we do not know exactly which CD it is (model specific?) it is hard to answer that. But you could, as Grant also said, use a Disk Tools floppy and the Apple HD SC Setup utility on it. However, at this stage (when the bootable hard disk is the only bootable disk at hand) it does not hurt to wait a little. Anyway, the Disk Tools floppy will have to be produced first, and that is a problem. You can not do this on a PC, since a built-in PC floppy drive is unable to handle the 800K Mac format, not even with special software for Mac disks. The same is true for external USB floppy drives, whether connected to a modern Mac or to a PC. The only way to create an 800K Disk Tools floppy is on an older Mac (look for a model with a floppy drive for both 800K and 1.44 MB).
If a completely fresh install to a System 7.5.3 is impossible, what recourse do I have in terms of upgrading the System from 6.0.8 to 7.5.3?
You could erase the hard disk, once a Disk Tools floppy is available, and then install System 7.5.3, This can be done from the CD (if a bootable floppy can be modified to hold a suitable CD-ROM driver) or from the nineteen files download (each file is too large for an 800K floppy and must thus be segmented or carried over via cable). As mentioned earlier, modifications et cetera require access to another Mac.
Does a version little bit earlier, like, 7.0.1 or something come with a CD-ROM driver extension on a "bootable" floppy (800k)so that I can first boot up with such floppy and then initiate reformat from the CD-ROM.
Not ready made with CD-ROM software. The System 7.0.1 disks at the Apple site are 1.44 MB. There are System 7 disks in the 800K format (in some language versions), but if I remember correctly, the Disk Tools floppy has a system file which is basically System 6. Any Disk Tools floppy will have to be modified. We will certainly find one way or another to create/modify a floppy, as soon as you have access to another Mac.
Also, I only have access to PC based machine connected to the internet. If I do download into my PC based system, is there a way to trasport such file onto a floppy disk on a PC system?
Due to the aforementioned absolute inability to handle the 800K Mac format, a PC is far from ideal in this very case. I would suggest that you look for another inexpensive (and functional) Mac from the period approx. 1991 to 1997 (perhaps an older PowerBook), e.g. through an online auction site.
A question in this context, though: Do you have a terminal emulator with file transfer capabilities for Mac on the hard disk (or possibly on 800K Mac floppies)? This could be a separate program or the communications section of e.g. ClarisWorks (I do not remember whether Microsoft Works for Macintosh contained a corresponding part). That would make transfers from other computers (including PCs) possible, or at least easier.
Jan