The more this goes on, the more annoying it gets. If 10.5.2 doesn't fix things, I'm taking it in. Here's more that I have noticed:
1) Location changes are just a red herring. Wake from sleep is the main culprit. I'll open up the MacBook, it will show 4 bars, then after a couple of minutes, things will pause and the signal strength would fall. At this time, everything pauses. It's not like it drops to one bar, though. It will often just fall to three bars, and maybe two bars. Afterwards, it will rise back to 4 and the connection will be ok until a few minutes later.
2) Being plugged in helps, but it is not the end all solution. It does stave off the drop periods for a bit longer, though.
3) Again, Airport Off/On does not help, but restarts resets the cycle.
4) There's a general signal strength issue. I'll sit upstairs with the MacBook, my girlfriend's MB Pro, and my G4 iBook. The MacBook is stuck at 3 bars while the other two sit pretty at a steady 4.