topmodel, first off I'd say don't apply generic sRGB or Adobe RGB profiles to your monitor as a partial solution. As you found out, they aren't useful in describing the output capabilities of modern displays. They should really only be applied to image files.
I suspect you have a corrupt or otherwise bad color profile for your monitor. You can check if your custom Dell profile is corrupt by opening Colorsync Utility, going to Profile First Aid, and clicking Verify.
Did you create the calibrated profile using a hardware colorimeter like the Spyder3 or eye1? If not, it's worth saying that sometimes a manufacturer's own "custom" profile is crap. I use a LaCie 319, which came with a profile that was supposedly designed for this model but instead makes everything very foggy. My previous NEC's profile didn't work at all.
Are you running a multi-display setup? I've been having color problems with mine since upgrading to Leopard. The Apple apps (preview, quicklook, safari) no longer distinguish between my two displays in terms of color. Colors show up as unnaturally muted and less contrasty on my laptop display if the external display is set as default in Colorsync Utility. Switch defaults and opposite happens: oversaturared on the desktop display. I'm all ears if anyone's run into the same problem.