I wouldn't be concerned about viruses on Macs. If you use an anti-virus program, you should think of doing so as a being a "good neighbor" to Windows-using colleagues (so you do not pass on a tainted emails and files). You won't be affected either way on your Mac.
Other types of malware (not viruses), such as trojans, can be a threat. These pretend to be something else to trick you into running them. Just pay attention to the warnings Mac OS X throws up. If it says program XYZ, which was downloaded from the Internet, is being run for the first time, and you don't know what program XYZ is, don't allow it to run. Or if Mac OS X asks you to give admin user authorization (username and password) at an unexpected time, don't give it.
For Mac OS X, common sense is better than Norton Anti-Virus.