FWIW, I was playing around with a friend's interface this past week. It's a newish interface, nothing fancy, but not too cheap either. Anyway, it has both balanced and unbalanced outputs. For some reason, hooking up the unbalanced outputs to the monitors had a weird noise on them, not a typical grounding noise, while the balanced outputs to the monitors was noise-free. Go figure.
So... if there is a choice, balanced is better!