Wow I found this forum and I don't even have an Apple product (am using Windows XP)... I have a similar problem.
I have a new m$ wireless laser mouse, using the Intellipoint driver that came with the mouse. (The generic mouse driver in Windows doesn't work right with the laser mouse. Previously I used a m$ wireless optical mouse. The generic windows mouse driver worked fine so I never needed to install the intellipoint software -- until now.)
With my prior mouse, the mouse action would acquire the window focus if needed, AND perform the single- or double-click action as was intended. This was with the windows generic mouse driver loaded, not the intellipoint software.
My old mouse is DOA, so I can't try it with the intellipoint software loaded. But it seems as if the change is that that the intellipoint will use the first click to acquire focus and do nothing more. Then the desired single- or double-click action must be performed, once the focus has been acquired. If the item already had the focus, no extra mouse clicks are required. (Perhaps that's why the person above can move a window around, and then the click 'works' -- the window now has the focus and will accept the 'clicks'?)
Can anyone confirm that is the same behavior with the intellipoint software? That extra clicks are required only when an item does not have the focus?
TIA,
--appyface