Hello,
I have bought the Macintosh version of Route66 software.
It work well for me.
http://www.66.com/route66/index.php
I use it with a Bluetooth GPS but I know it also work with most GPS.
If you go on their Website in the FAQ for Mac , you will find:
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1. Which GPS devices are supported?
All GPS receivers that meet the following requirements can be used with “ROUTE 66 Route 2004”:
Protocol: NMEA-0183 v2.0 or higher (RMC, GSA, GSV)
Map datum: WGS84
Baud rate: 4800 – 115200 bps
If you are looking for a USB GPS receiver, please check if the GPS manufacturer provides a driver for its device.
Please note that the following GPS receivers are not compatible with "ROUTE 66 Route 2004":
DeLORME Earthmate USB
Garmin USB
Navman USB
The Bluetooth GPS receivers that meet the above mentioned requirements are compatible with the "ROUTE 66 Route 2004" software and do not require additional software to work.
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Other software might support other GPS.
Very few software are currently working on Mac and if you are looking for street, I think Route66 is probably the best you will find. If you are looking for other type of use, like for Topo map, then other software solution exist.
I have also use my GPS with Virtual PC and it work too.
Hope this will help you.
Franco