Memory Allocation problems
Over the time you use the computer, it gradually becomes slower and slower, and it seems as if Mac OS is using virtual memory. Checking in Activity Monitor, the RAM use is almost 100%, leaving possibly only an extreme minimum quantity of ram free (10 or so MB). In my case, i've seen this on computers with ram ranging from 256MB to over 1.5GB. Having only a few programs running the use of the RAM at those levels is impossible.
There is a way around this though, but it's not permanent. I've run Disk utility and chose "Repair Permissions" in the screen. Once it starts (ie when the meter starts to fill up), the ram is literally instantly freed to levels that are much more acceptable (at times 50% to 70%+ is freed instantly, indipendant of RAM quantity).
I've noticed in these forums people complaining on similar problems of computers slowing down and higer virtual memory use. With this work around of using Disk Utility one can possibly get around those problems. But like i'm saying, it seems to be a MUCH larger problem relating to Tiger's memory allocation and the apparant inability to free up memory used by applications that have been closed.