Thanks for your thoughts.
Yes, Safari crashes a LOT - probably 5-6 times a day if I'm looking at YoouTube or Google Videos over about 10 minutes long.
No, like I said, I have tried running with no other applications running and I still have the problem. I suspected that Safari might be causing everything because it very often gives me a beach ball when I'm just scrolling down a page or filling in an online form - but not having Safari running didn't help.
I rarely reboot unless I really have to - such as the odd occasion when absolutely nothing is happening, the dock stays hidden, application windows don't come to the front when clicked and the clock stops for more than a minute or so. But that is rare. I haven't had a kernel panic for at least a month.
Files don't crash in the same place and the same file will crash with both VLC and Quicktime. There isn't a single video file over about 20 minutes that I have tried to play in the last month which hasn't crashed whatever application I have been using. I simply have to get back on the horse where I fell off and wait for the next crash.
I spent about 12 hours yesterday running every maintenance routine from repairing permissions and disk repair to the full TechTool Pro suite on each of the four hard drives I have installed.
The free memory on each is as follows:
1) 29/112 Gb (main drive, system etc)
2) 237/375 Gb (Time Machine back up only)
3) 12/112 Gb (iTunes library, GarageBand loops only)
4) 70/288Gb (video archive and secondary start up disk)
All figures rounded up and drive total space (second figure) is formatted capacity.
I haven't tried to watch anything since my marathon maintenance but I will do later on today - I have to watch something quite long and expect a crash somewhere between 20 and 30 minutes. I'll file a report.
Thanks for your help.
P.S. You don't have any thoughts on this little baby, do you:
http://discussions.apple.com/thread.jspa?threadID=1573185