I had a game that required 5cds.
Obviously, playing the disk swap was annoying, I tried copying all 5 CDs to a single DVD. No joy. The game wanted the individual CD to be mounted.
One thing I had at the time was lots of free drive space, so ...
1. I created disk images for each of the 5 cds.
2. Recorded an applescript that on execute, opened each of the 5 images, then
ran the game from the applications folder.
(at this point, the script would suspend...when the game quite, the applescript resumed)
3. where it closed and dismounted the images.
I named the script the same as the game, and used the same icon.