Depends on which Intel Mac you have.
Mine has two FireWire 400 ports.
The more recent models have one FireWire 400 and one FireWire 800 port. The FireWire 800 port looks different; it's rectangular. You can use a cheap adapter to convert from FIreWire 800 to 400.
If your current hard drive is a 3.5-inch drive, the enclosure probably has a daisy chain port (and extra FireWire port). So one option is to connect your new drive to the back of your existing drive.
Another option is to get a self-powered FireWire hub. For example
http://www.amazon.com/Belkin-FireWire-6-Port-Hub-F5U526-APL/dp/B0006BHCEK/ref=pdbbs_sr1?ie=UTF8&s=electronics&qid=1227916824&sr=8-1
And yet another option is for use USB 2.0. I've been using one external drive through USB recently, and it works just fine. It's supposedly slower and less efficient than either FireWire 400 or 800, but for casual use, it seems just fine.