Unfortunately, I'm not sure there's a 100% problem-proof audio interface. Although I always thought MOTU were rock-solid, there's currently a problem with 828mkII, 828mkIII and Ultralite. It generates a digital screech quite often and there's no solutionn yet. It happens either on Mac or PC and I know at least two different people with two different setups with the same exact problem. There's a two-page topic at Motunation about that problem. We'll probably have to wait for a firmware or drivers upgrade. I don't want to put down MOTU but I just want to show that there will be always problems with one or either, depending on how lucky we are...seems the computers' fate...!
That said, although I still hate the breakout cable, I have yet to find something better than the Duet.