From the Finder type shift-command-G or Go->Go to folder...
/var/folders/IZ is the path. Within the IZ folder you will see another folder with a very long, random character name. Open that folder and you will a folder named -Caches-. Within the -Caches- folder you find the folder com.apple.Safari. Inside the com.apple.Safari folder are the files Cache.db and SafeBrowsing.db. These are Safari's actual caches in Leopard. This is also the reason some people are having trouble with Safari 3.2. If they have disabled Safari's cache using the terminal or a utility like Onyx, Cocktail, or any of the other Safari utilities that disable the cache then Safari 3.2 can't access the SafeBrowsing.db and apparently crashes. This is also why turning off the fraudulent website preference causes some user's Safari to start working again. And of course, a whole lot of people were obsessed with speeding up Safari and took bad advice to disable the cache, then promptly forgot they did so. Then when Safari 3.2 blew up in their faces they had no clue. Combine that with all the third-party add-ons and, well, you get the picture.
Trashing the Cache.db and the SafeBrowsing.db files may also be a good troubleshooting tool. But remember, we're talking Leopard only, not Tiger.