In safari go up to the top bar and click on the word Safari/Reset Safari, and then it will prompt you which things you want to delete from Safari's caches, then just hit ok.
Don't check all the boxes unless you're sure you know what all your usernames/passwords are for your various websites. With every item checked those will be deleted as well.
To delete the cache/history/cookies/favicons of browsers other than Safari use OnyX. Here's a link to the VersionTracker download page for OnyX: http://tinyurl.com/4abor.
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how do i Clean Temporary Internet files and Empty my Cache
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