If you couldn't open the Finder then you wouldn't have gotten this far. If you are running Firefox, iTune, and Safari it can't be that unresponsive.
Try this -
If you have any external drives or anything else physically connected to your machine, disconnect them. Restart your computer. After it has restarted, run Console.app. Click "Show Log List" then click "All Messages" under "LOG DATABASE QUERIES". Find the first message printed since your reboot. It should look something like this:
1/11/09 10:56:08 AM kernel Darwin Kernel Version 9.4.0: Mon Jun 9 19:30:53 PDT 2008; root:xnu-1228.5.20~1/RELEASE_I386
Select all those message, copy, and paste them here. You can't just say "alot of other messages". You must be specific.
If you are having serious system trouble, you don't want to go running lots of applications - especially not at the same time. How does your system run when you aren't running any applications? At what point does it start running poorly?