The Sims 2 won't launch since I updated to Quicktime 7.6 on OS 10.4
However simply reinstalling The Sims 2 will not fix the problem if you have updated to Quicktime 7.6. Unfortunately I found the only way to get the Sims running again on OS 10.4 was to remove Quicktime 7.6 and to reinstall an earlier version (Quicktime 7.5.5 or earlier). This is not as easy as removing Quicktime 7.6 from your Applications folder and com.apple.QuickTime.plist in the User/Library/Preferences or using a program like Appzapper ( http://www.apple.com/downloads/macosx/systemdiskutilities/appzapper.html). When you go to reinstall an earlier version of Quicktime it will say, "unable to install because a more recent version is already installed".
So, the only way to reinstall an earlier version of Quicktime is to reinstall the system software (in my case OS 10.4) using the reinstall and archive option on the OS 10.4 Installer DVD.
Hope this saves some of you some time finding a solution!
MacBook Pro (G4), Mac OS X (10.4.11)