http://www.keynoteuser.com/2005/08/03/logitech-cordless-24ghz-presenter/
this is an old review, but yes, it works, or at least the version I had at the time worked. I also know as recent as about 6 months ago the Gideon's of Canada bought a bunch for their presenters, and they all use Keynote. Still, I can't guarantee that it'll work.
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