Preview Commands Grayed Out
This does not change, regardless of tool selected or whether a portion of the image has been highlighted or not.
It does not matter whether a JPEG or a PNG image is the current file opened.
Similarly, the "Select" and "Annotate" buttons do not work. Clicking on the "Select" button has no effect, and the "Annotate" button is stuck on the elliptical shape and does not drop down, either.
This was precipitated I think by Mac OS X 10.5.6. It was an update on my MacBook, and it came pre-installed in my iMac. Both macs exhibit this problem since 10.5.6.
iMac 3.06GHz (2009), Mac OS X (10.5.6), 4 FW HDs, Miglia Diva speakers, EPSON Scanner, Xerox Phaser
