I have this same question. I have a late-2008 unibody MBP 15, and 6GB of RAM. However, I have observed some instability with 6GB (kernel panics). I'm not sure what to point the finger at. I ran memtest86 overnight without any errors. The memory is Corsair. So, I'm not even sure it's the memory causing the issues.
Most often the kernel panics are from the mdworker or Parallels processes -- both of which are notorious for causing kernel panics.
Anyway, I was also curious whether anyone else has speculation on "Slot 0" vs "Slot 1". So far, I've only run it in "Slot 1". Currently, I've yanked the 4GB DIMM from the MBP and am running back at 4GB (2x2GB).