Many thanks in advance for your attention.
Maybe this will add some clues as to the mystery:
1. Since I updated to iTunes 8.2.1, I also have had the following bug whenever I try to sync my iPod Touch (2G). "The iPod " " cannot be synced - An unknown error occurred (-50)." pops up.
2. I have a file in iPhoto of just photos for my iPod (instead of the entire - huge - iPhoto Library.) Under iTunes, looking under the Photos Tab, this choice was "selected albums" - which allowed you to pick just one album from one's iPhoto Library to be synced. But this choice, the button, is now greyed out. It is there, so one can no longer select it.
3. ?
4. On top of that, it seems the default checkbox- "Sync All Photos from iPhoto" was automatically selected after the iTunes update. (I think this is the cause for the -50 error). I never intended to have my whole iPhoto library automatically imported by my iPod. I think the poor iPod is overwhelmed by the number of photos it suddenly is called on to import. Or - I have photos in my iPhoto Library - never intended for the iPod - that the iPod cannot import.
4. As others have done here, I turned off "Sync Photos" from iPhoto.
5. Then when I try to sync, no problem, no hitches. No Error prompts. Great.
6. But - this way, I am forever stuck with the photos that are in my iPod now. Adding new photos seems impossible, as the sync Selected Albums button is greyed out. I never would want my whole iPhoto Library in my iPod. I would never want just the Most Recent Photos (another option- which you can choose - but seems to me idiotic).
7. Are we overlooking something? From other posts, it seems this is a bug that is widespread.