Cleaning up Disk Space

Please forgive me that I'm not aware of all the Mac features yet... I just made the switch from PC to Mac not all that long ago.

Question: What's the easiest way to clean up disk space from my internal hard drive? I feel like I have some applications I've installed, but not really using, and I'd like to possible remove them. Windows has the Change/Remove Software window, and I'm wondering if there is a Mac equivalent?

Any other suggestions that would help me learn how to minimize the disk space I'm using will help. Muchos Gracias.... or, if you prefer, Thanks!