Well, for me Mainstage 1 worked quite nicely since it came out for just this. I've basically been using it as a live digital mixer, with 2 Presonus Firepods as an aggregate device. My 2.6ghz MBP with 4gb was able to do 4 vocals, with individual compression, and 2 acoustic guitars, & 1 upright bass. Also, playing back exs24 samples with a fcb1010. Was able to use 48k, 128 buffer. Latency was noticeable by me (because I knew it was there), but the rest of the band said they couldn't tell. Set up to send a monitor mix to 2 wedges, and another to in ear monitors. All worked fine, until Mainstage 2 ... you can see my other thread about maxed CPU for info on that.....basically unusable now. So, MS1 = yep, MS2 = maybe (but not for me yet)