I liked the idea of no-script but ended up uninstalling it. Just about all sites have scripts of some sort these days and on 90% of the sites I visited I was having to constantly mark exceptions to get basic functionality.
Download the latest version of Firefox. Install Adblock, and install NoScript, which are ad-ons designed for Firefox, available on the Firefox website. You will be amazed at what happens as you surf. In my machine, I have Safari, Opera, iCab, Firefox, Camino, and SeaMonkey. You can use any one at time, or even have two or more open and on the net at once. Don't be afraid to try them one and all. Firefox is a good alternative to Safari, once you set it up right, I doubt you will use Safari anymore. Have fun. P.S., if you REALLY want to get rid of all junk, you can download Wannabe.PPC.1.0b14, which will run in Classic mode. I absolutely positively guarantee 100% no pop-up windows ever. But I don't think you will want to work with that browser, it's a very very basic text browser.