Unfortuantely, that's like asking if the Mac can run "software". The answer is yes, but it's naive in that it doesn't answer the question whether it can run the software you're interested in running.
DRM (Digital Rights Management / Digital Restrictions for Media / Fair-Use Circumvention Kits) refers to any number of technical schemes to deprive the end-user of certain rights with regard to access and use of digitally stored media. It's not a technology in and of itself and come in many forms, from simple key-based methods, to ones that, when you install them, explicitly subvert the security on your computer, patch hardware drivers, and grants control of your system and it's contents to the broadcaster (Sony, famously installed trojans and rootkits on unsuspecting Windows-user's computers that not only made them susceptible to being taken over by hackers, but also destroyed files on the person's computer).
Since you have a specific DRM plug-in in mind, why not enquire as whether a Mac version of it exists. You should also make an effort to determine if the DRM technology is passive (such as a key or watermarking method), or active (it modifies the operating systems, monitors your activity, sends details of your identity and contents of files on your computer to the media provider or a third-party).