Go into System Preferences => Network => Airport (in left column) =>Click the pinwheel beside the Plus/Minus sign and select make service inactive should do it.
We are assuming by wireless you mean wi-fi, if so follow Bob's suggestion. If you mean Blue Tooth (another wireless technology) which is used for your wireless keyboard and mouse you would go to:
System Preferences, Bluetooth, uncheck the On box and uncheck the Discoverable box.