1. Active it!
2. Enable it to connect to your wireless network if you have one.
3. Got Mobile Me? Active it and sync up your goods. If not, at least set up one e-mail account. I can't answer for gmail, but with Yahoo, it's flawless. Read on one machine, it's marked read on all. Delete in one place, it is deleted in all.
4. Got a few songs in iTunes? Sync at least one up, maybe an entire album or short playlist.
5. Got a movie? Sync up just one movie.
6. Got pictures? Pick a small selection of photos to sync up.
7. Sync all of the above. Now you have a nice selection of various things to play with.
8. Download iBooks. With the free free Winnie the Poo book at least, give a nice example of what can be done with pictures and such.
9. Now that you are loaded up, if you have family tell them to leave you alone for the rest of the night, you are busy. Find a comfy couch or bed, your favorite drink, small snack tray, and call in late or sick tomorrow for work/school.