-= Guaranteed Solution =-
Hi, I have a Quick and nasty solution. It will work, it's a good test also if this is not the case, however, I bet it is.
The problem is technically a ground loop (
http://en.wikipedia.org/wiki/Groundloop%28electricity%29).
The 'Quick and Dirty' solution is to buy a normal cheap double adapter, cut off the earth (I just used pliers) and plug the power of your iMac into this and then your socket, effectively, removing the ground plug to the Mac.
I have messed around ALOT. This is the cheapest complete fix. Be careful when you plug USB's into the computer. I now use a hub for USB, as without the earth you will get some sparks from the ungrounded mac aluminum frame, If this happens don't worry but yeah its not ideal.
If this test works I would then recommend getting a decent RCA Ground noise filter, I don't know if it will cut frequency's of the audio or not, I guess the other option is to try a fully reconditioning UPC unit I haven't tested this yet, I just assume it would work. (cost $200-$600+)
You can also try plugging the Monitors and iMac into the same power board or even better same split power cable. this might have some effect until you really increase power output as the earths are as close to each other. This works for me until I turn my Mackie MR8's up to about 75%. if they are plugged into different power supply I can hear the noise at around 25%-30%.
The iMac actually has an impressive sound card, I have a feeling either it or something on the USB is leaking earth onto the aluminum frame. maybe even the sound card itself isn't earthed properly and runs through the USB earth. It annoys me mac won't provide any kind of solution or admit any of this. ****, I would be happy if they at least sold a ground loop filter on there shop. I know I'm not the only person with Monitor setup and iMac 27" !!!!