I have a Mac Mini late 2018 with the i7. It's hooked up via thunderbolt to a GPU in a Sonnet Breakaway box and a bunch of drives in a Thunder Bay enclosure, also via thunderbolt.
When I first got the computer, it was having occasional failures to connect to the Drives after restart, but more recently it's the eGPU that doesn't start up when the Mac Mini does.
Another problem I've had is the computer spontaneously shutting down every so often, most recently while I was reading something in a browser window.
In my many hours of conversations with various levels of tech support, I've found that Apple takes no responsibility for any of these problems and claims ignorance of any known issues.
However, on speaking with peripherals manufacturers and others, there seems to be a strong suspicion that it's something to do with the Mac Mini's T2 security chip.
The fix for the eGPU or Drives not connecting on startup is always to shut down the computer then unplug peripherals for 10 seconds then plug them back in and restart all together.
I just got off the phone with Apple re: spontaneous shutdown, and he had no idea how to fix it. He had me reset the PRam (unplug unit for 10 seconds then plug in and startup). Then he had me run disk first aid on Macintosh HD and then restart, after which he said that should solve it, but if it doesn't, I'd need to reinstall MacOS. That's all well and fine except for the fact that I've already done all of those things and yet the problems persist.
Hopefully Apple can fix these T2-suspected issues in future OS updates. Fingers crossed.
Does anyone knows a true solution that's available now?