Safari won't launch
After upgrading to Mojave 10.14.3, Safari no longer launches. Launching from Finder generates a "Safari is not open" message.
MacBook Pro 15", 10.14
Try downloading this program which was written by Thomas R, a long time poster. The program will search for malware/adware The program will do the work for you which makes it easy.
Malwarebytes Anti-Malware for Mac 10.10 and later
Try setting up another admin user account to see if the same problem continues. Please post back on whether or not this worked. Also try the Safe Mode. Please post back on whether or not this worked.
Isolating an issue by using another user account
If it works in the Safe Mode, try running this program when booted normally and then copy and paste the output in a reply. The program was created by Etresoft, a frequent contributor. Please use copy and paste as screen shots can be hard to read. Click “Share Report” button in the toolbar, select “Copy to Clipboard” and then paste into a reply. This will show what is running on your computer. No personal information is shown.
Etrecheck – System Information
If the log won’t post, try posting it in Pastebin and provide a link in a reply Pastebin