cache folders

Restarting in Safe Mode will clear any corrupt caches. Please try this first.

Use safe mode to isolate issues with your Mac

located at: https://support.apple.com/en-us/HT201262

If the problem persists, then please do the following:

Please navigate to the Mac App Store and download the free version of EtreCheck OR please click www.EtreCheck.com where you will find the app. Once you downloaded the free app and created the report please post it as your reply to this post. In order to post it, please use the following link for more detailed instructions on how to correctly post the results: 

https://discussions.apple.com/docs/DOC-250000211

We can then look for obvious issues that may be causing your problem.

Because cache files are intended to speed up performance, clearing them is not likely to help.

Ways to Help Make a Slow Mac Faster

1. 17 Reasons Why Your Mac Runs Slower Than it Should
2. Slow Mac Performance? This Article Solves It!
3. Fix slow start-ups in OS X | MacFixIt - CNET Reviews
4. How to fix slow shutdown and startup times. | MacTip.net
5. 6 Easy Tips to Speed Up OS X Yosemite on Your Mac
6. OS X El Capitan- If your Mac runs slowly
7. Visit The XLab FAQs and read the FAQ on Performance
8. Tips to Fix Issues that affect Mac Performance
9. Avoid using any third-party cleanup software. Usually, this software does more bad than good. You don't need it. All computers become slower over time even under normal use. Experienced users erase the hard drive and do a clean install from scratch from time to time; or whenever installing a major OS upgrade. Doing so means you must maintain regular and multiple backups.
10. If you have enabled iCloud Disk and are storing your Documents and Data in iCloud, then consider turning that off and signing out of iCloud. It can slow down the computer considerably. Please see the following from the user, fotomac: "The solution was to SIGN OUT of iCloud and my problem STOPPED! NO MORE SPINNING BEACHBALL! My computer's speed increased to what it should be and all my Apps now work!"
11. Add more RAM or cut back on the number of concurrently running applications and utilities. Remove unnecessary anti-malware software and any software that promises to clean your Mac. Check for runaway processes: Runaway applications can shorten battery runtime, affect performance, and increase heat and fan activity. Also, visit The XLab FAQs and read the FAQ on dealing with The Spinning Beach Ball of Death.
12. The Ultimate Fix: Backup everything, erase the drive, reinstall OS X, and restore your data from the backup. Reinstall third-party software from original media/scratch.