Picture-in-picture video playback buggy since updating to 12.2. Other issues since updating.

Some suggestions to try…

Since updating to 12.2 on the iPad Pro that I bought around the end of 2018, picture-in-picture playback is no longer possible with the YouTube app.

Watch YouTube videos in Safari instead of the app. This has the advantage of not being limited to PIP only in the YouTube app. To initiate PIP in Safari tap the video player to display the player controls. Tap the fullscreen button in the lower right.

Tap the PIP button in the upper left.

Since purchasing this thing, I hav3 been able to simply press the home button while watching Netflix and the little overlay video box would automatically pop up and continue playing whatever I was watching. This no longer happens and I can't figure out why not.

To initiate PIP while in the Netflix app, while a video is playing, either swipe up from the bottom edge of the screen with one finger or use a four finger pinch.

Something I do pretty much every night is fall asleep with something playing on either Netflix or YouTube, I turn my screen off and just listen to the audio untilI pass out. Since applying the 12.2 update, I can no longer do this. Netflix simply won't play with the screen turned off anymore, while YouTube will play for a few seconds–maybe a minute or two–and then starts pausing constantly like described above in the PIP issue.

For the Netflix app, while a video is playing or paused in fullscreen, press the iPad’s Sleep/Wake button. The screen will go dark and the video if playing will stop. Press the Sleep/Wake button again. Tap the play button on the player screen overlay. Press the Sleep/Wake button once again. The screen will go dark but the video sound will keep playing. While a video is playing or paused in PIP, swipe down with one finger from the top edge of the screen. Tap the play button on the player screen overlay. Press the Sleep/Wake button and the screen will go dark but the video sound will keep playing.

For YouTube on Safari, while a video is playing, either fullscreen or PIP, press the iPad’s Sleep/Wake button.. The screen will go dark and the video will stop. Press the Sleep/Wake button again. A pause button will display in the player screen overlay. Tap it and the play button will display. Tap the play button. Press the Sleep/Wake button once again. The screen will go dark but the video sound will keep playing.

The player screen overlay:

Try a separate YouTube PiP app called CornerTube in the iOS App Store.

CornerTube - PiP for YouTube by Tiny Whale Pte. Ltd.

https://itunes.apple.com/us/app/cornertube-pip-for-youtube/id1073199994?mt=8

This is what I use.

Works when the screen is asleep, too!

Best of Luck to You!