Hi there TimAbrahamson,
Thank you for using the Apple Support Communities. I see you're running into some issues with your iTunes media folder.
If I understand correctly, you're setting the media folder location to the F drive and it seems to work as expected, but then it changes back to a folder on your C drive the next time you start iTunes. Are you using the steps here to set your location? Change where your iTunes files are stored on PC
Is the F drive external? Is it always connected to the PC?
If you quit iTunes and re-launch while holding Shift, this should bring up a list of different iTunes libraries. Do you have more than one available? I'm wondering if you may have one library that defaults to the F drive and one to the C drive.
Also, have you made sure your library on the F drive is consolidated? This is another possible factor to check into, covered here: Back up and restore your iTunes Library
I hope this helps get you started!
Kind regards.