Safari does not open on my Macbook

Will it open if you try to open it from the Applications folder? The Dock alias may be corrupt.

Try setting up another admin user account in System Preferences/Users & Groups to see if the same problem continues. Please post back on whether or not this worked. Also try the Safe Mode. Please post back on whether or not this worked.

Isolating an issue by using another user account 

Safe Mode - About

If it works in the Safe Mode, try running this program when booted normally and then copy and paste the output in a reply. The program was created by Etresoft, a frequent contributor.  Please use copy and paste as screen shots can be hard to read. Click “Share Report” button in the toolbar, select “Copy to Clipboard” and then paste into a reply. This will show what is running on your computer. No personal information is shown. If the log won’t post, try posting it in Pastebin and provide a link in a reply. After pasting the report in a PasteBin page, go to the top of the page, and copy the address in the URL bar. Paste that in a new reply.        Pastebin

Etrecheck – System Information

You are welcome. Quit Safari. Control - click on the Dock icon, select Options, and then uncheck Keep in Dock. See if the Dock icon disappears. If it doesn't, hold down the command key while clicking and holding down on the Dock alias. Then drag the alias from the Dock until it disappears. You may have to drag it fairly far from the Dock. Once the alias is gone, drag Safari from the Applications folder to the Dock to create a new alias. Select Keep in Dock from the Options if desired. Test.

You are welcome.