Safari doesn't respond to the mouse click.

Try setting up another admin user account in System Preferences/Users & Groups to see if the same problem continues. Please post back on whether or not this worked. Also try the Safe Mode. Please post back on whether or not this worked.

Isolating an issue by using another user account 

Safe Mode - About

If it works in the Safe Mode, try running this program when booted normally and then copy and paste the output in a reply. The program was created by Etresoft, a frequent contributor.  Please use copy and paste as screen shots can be hard to read. Click “Share Report” button in the toolbar, select “Copy to Clipboard” and then paste into a reply. This will show what is running on your computer. No personal information is shown. If the log won’t post, try posting it in Pastebin and provide a link in a reply. After pasting the report in a PasteBin page, go to the top of the page, and copy the address in the URL bar. Paste that in a new reply.        Pastebin

Etrecheck – System Information

You might want to start your own post. A new post would be much more visible. You can link to this one.

Bluetooth devices become unresponsive

Bluetooth Interference Sources

Bluetooth Interference Sources (2)

If your Wi-Fi is capable of generating a 5 GHz signal, try that.

You are welcome. If you would post how you fixed it, it might help others.

my bluetooth 2 is dead & need to be recharged. How can I do it?